Article
The non-transmembrane form of Delta1, but not of Jagged1, induces normal migratory behavior accompanied by fibroblast growth factor receptor 1-dependent transformation.
The Journal of biological chemistry - 2 Apr 2004
Trifonova Radiana, Small Deena, Kacer Doreen, Kovalenko Dmitry, Kolev Vihren, Mandinova Anna, Soldi Raffaella, Liaw Lucy, Prudovsky Igor, Maciag Thomas
Abstract excerpt
The interactions between Notch (N) receptors and their transmembrane ligands, Jagged1 (JI) and Delta1 (Dl1), mediate signaling events between neighboring cells that are crucial during embryonal development and in adults. Since the non-transmembrane extracellular form of J1 acts as an antagonist o...
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