Article
Identification of a novel mechanism of regulation of the adherens junction by E1A, Rac1, and cortical actin filaments that contributes to tumor progression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 1998
Fischer R S, Quinlan M P
Abstract excerpt
Transformation progression toward more malignant behavior often results from a loss of epithelial cell behavior, especially cell-cell adhesion. E1A cooperates with ras to transform primary epithelial cells such that they maintain epithelial cell differentiation, including the proper localization...
Topics
- Actin Cytoskeleton
- Adenovirus E1A Proteins
- Animals
- Cadherins
- Cell Line, Transformed
- Cell Membrane
- Cortactin
- Cytoskeletal Proteins
- Cytoskeleton
- Disease Progression
- Exocytosis
- GTP-Binding Proteins
- Gene Expression Regulation
- Genes, ras
- Intercellular Junctions
- Intracellular Fluid
- Microfilament Proteins
- Peptides