Article
Elevated stromelysin-1 and reduced collagenase-IV expression in invasive rat embryo fibroblasts expressing E1A deletion mutants + T24-H-ras.
International journal of cancer - 9 Jul 1992
Engel G, Popowicz P, Marshall H, Norling G, Svensson C, Auer G, Akusjärvi G, Linder S
Abstract excerpt
We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of...
Topics
- Adenovirus Early Proteins
- Animals
- Base Sequence
- Blotting, Northern
- Cell Transformation, Neoplastic
- Embryo, Mammalian
- Exons
- Fibroblasts
- Fibrosarcoma
- Gene Expression
- Genes, ras
- Matrix Metalloproteinase 3
- Matrix Metalloproteinase 9
- Metalloendopeptidases