Article
A mutant E2F-1 transcription factor that affects the phenotype of NIH3T3 fibroblasts inefficiency associates with cyclin A-cdk2.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 1998
Jordan-Sciutto K L, Hall D J
Abstract excerpt
The amino-terminal domain of the E2F1 transcription factor is the site of association with cyclin A-cdk2, mapping to residues 87-94. A mutant of E2F1 lacking the first 87 amino acids (termed E2F1d87) has a number of potent effects on cellular phenotype when constitutively expressed in NIH3T3 fibr...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- CDC2-CDC28 Kinases
- Carrier Proteins
- Cell Cycle
- Cell Cycle Proteins
- Cyclin A
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Mice
- Molecular Sequence Data
- Mutation
- Phenotype
- Protein Binding