Article
Cyclin A levels, the duration of S phase and sensitivity to a chemotherapeutic agent are altered in fibroblasts cultured on a fibronectin matrix.
International journal of oncology - 1 Sept 1998
Min I, Stubbs M C, Strachan G D, Hall D J
Abstract excerpt
Culture of murine embryonic fibroblasts, but not vascular smooth muscle cells, on a fibronectin matrix significantly shortens their transit time through the S phase of the cell cycle. This shortening corresponds to an increase in both cyclin A protein levels and active cyclin A/cdk2 complex. The...
Topics
- 3T3 Cells
- Animals
- Antineoplastic Agents, Phytogenic
- CDC2-CDC28 Kinases
- Camptothecin
- Carrier Proteins
- Cell Cycle Proteins
- Cells, Cultured
- Cyclin A
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Extracellular Matrix
- Fibronectins
- Mice
- Mutation