Article
Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells.
Molecular biology of the cell - 1 May 1995
Kato M, Saunders S, Nguyen H, Bernfield M
Abstract excerpt
Simple epithelial cells are polygonal in shape, polarized in an apical-basal orientation, and organized into closely adherent sheets, characteristics that result from a variety of cellular specializations and adhesive proteins. These characteristics are lost when the epithelia transform during embryogenesis into mesenchymal cells or after neoplasia into invasive carcinoma cells. Of the syndecan family of...
Topics
- Actins
- Animals
- Cadherins
- Cell Adhesion
- Cell Line
- Epithelial Cells
- Genetic Vectors
- Integrin beta1
- Integrins
- Mammary Glands, Animal
- Membrane Glycoproteins
- Mesoderm