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Article

Differential cell cycle effects induced by E2F1 mutants.

Oncogene - 9 Jan 1997

Qin X Q, Barsoum J

Abstract excerpt

Expression of two types of transactivation-defective E2F1 mutants in human Rb-/- tumor cells led to an increase in the proportion of cells in the G1 phase of the cell cycle as determined by FACS analysis. Experiments revealed two different mechanisms of action. One mutant type induced a G1 arrest after the restriction point, with cells phenotypically at a cell cycle stage later than G1. The action of this mutant...

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Identifiers

PMID: 9010232
DOI: 10.1038/sj.onc.1200809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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