Differential cell cycle effects induced by E2F1 mutants.

doi:10.1038/sj.onc.1200809

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Article

Differential cell cycle effects induced by E2F1 mutants.

Oncogene - 9 Jan 1997

Qin X Q, Barsoum J

Abstract excerpt

Expression of two types of transactivation-defective E2F1 mutants in human Rb-/- tumor cells led to an increase in the proportion of cells in the G1 phase of the cell cycle as determined by FACS analysis. Experiments revealed two different mechanisms of action. One mutant type induced a G1 arrest...

Topics

Carrier Proteins
Cell Cycle Proteins
DNA-Binding Proteins
E2F Transcription Factors
E2F1 Transcription Factor
G1 Phase
Humans
Phenotype
Retinoblastoma Protein
Retinoblastoma-Binding Protein 1
Transcription Factor DP1
Transcription Factors
Transcriptional Activation
Transfection
Tumor Cells, Cultured
Tumor Stem Cell Assay

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