Article
In silico analysis of peptide binding features of HLA-B*4006.
Indian journal of experimental biology - 1 Feb 2012
Gadewal Nikhil S, Joshi Narendra N
Abstract excerpt
HLA-B*4006 is the most common allele amongst Indians. It belongs to the 'HLA-B44 supertype' family of alleles that constitute an important component of the peptide binding repertoire in populations world over. Its peptide binding characteristics remain poorly examined. The amino acid sequence and structural considerations suggest a small, poorly hydrophobic 'F' pocket for this allele that may adversely affect the...
Topics
- Alleles
- Amino Acid Sequence
- Computational Biology
- HLA-B Antigens
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutant Proteins
- Peptides
- Protein Binding
- Thermodynamics
