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Article

The Peptide Repertoires of HLA-B27 Subtypes Differentially Associated to Spondyloarthropathy (B2704 and B2706) Differ by Specific Changes at Three Anchor Positions

1 May 2002

Abstract excerpt

HLA-B*2704 is strongly associated with ankylosing spondylitis. B*2706, which differs from B*2704 by two amino acid changes, is not associated with this disease. A systematic comparison of the B*2704- and B*2706-bound peptide repertoires was carried out to elucidate their overlap and differential features and to correlate them with disease susceptibility. Both subtypes shared about 90% of their peptide...

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Identifiers

PMID: 11875071
DOI: 10.1074/jbc.m200371200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Peptide Repertoires of HLA-B27 Subtypes Differentially Associated to Spondyloarthropathy (B*2704 and B*2706) Differ by Specific Changes at Three Anchor PositionsPMID 11875071Read ↗

Binding of peptides naturally presented by HLA-B27 to the differentially disease-associated B*2704 and B*2706 subtypes, and to mutants mimicking their polymorphism.Semantic proximity Read ↗

Susceptibility to ankylosing spondylitis correlates with the C‐terminal residue of peptides presented by various HLA‐B27 subtypesSemantic proximity Read ↗

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The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position.Semantic proximity Read ↗

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