Binding of peptides naturally presented by HLA-B27 to the differentially disease-associated B*2704 and B*2706 subtypes, and to mutants mimicking their polymorphism.

doi:10.1111/j.1399-0039.1996.tb02664.x

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Article

Binding of peptides naturally presented by HLA-B27 to the differentially disease-associated B2704 and B2706 subtypes, and to mutants mimicking their polymorphism.

Tissue antigens - 1 Nov 1996

Galocha B, Lamas J R, Villadangos J A, Albar J P, López de Castro J A

Abstract excerpt

B*2704 and B*2706 are closely related HLA-B27 subtypes of which the former but not the latter is associated to ankylosing spondylitis. Their peptide specificity relative to other disease-associated subtypes was analyzed by testing binding of self-peptides naturally presented by B*2705 or B*2702,...

Topics

Antigen Presentation
HLA-B27 Antigen
Humans
Molecular Mimicry
Mutation
Peptides
Polymorphism, Genetic
Spondylitis, Ankylosing
Tumor Cells, Cultured

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