Article
Biochemical and structural impact of natural polymorphism in the HLA-A3 superfamily.
Molecular immunology - 1 Jul 2005
Li Lenong, Bouvier Marlene
Abstract excerpt
Class I alleles of the HLA-A3 superfamily (-A*0301, -A*1101, -A*3101, -A*3301, and -Aw*6801) share largely overlapping peptide repertoires. Cross-reactive T cell responses between HLA-A3-like molecule/peptide complexes have been demonstrated in vitro and during natural diseases. In spite of this immune relatedness, HLA-A3-like molecules exhibit noticeable differences in their antigen-selecting and -presenting...
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