Article
Differences in peptide presentation between B27 subtypes: the importance of the P1 side chain in maintaining high affinity peptide binding to B*2703.
Immunity - 1 May 1994
Colbert R A, Rowland-Jones S L, McMichael A J, Frelinger J A
Abstract excerpt
Susceptibility to spondyloarthropathies is strongly associated with the MHC class I molecule HLA-B27, and is hypothesized to result from the presentation of arthritogenic peptides. Subtypes of B27 that differ structurally but are disease-associated ought to be capable of presenting such peptides,...
Topics
- Alleles
- Amino Acid Sequence
- Antigen Presentation
- Arthritis
- Base Sequence
- Binding Sites
- DNA
- HLA-B27 Antigen
- Humans
- Influenza A virus
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Nucleocapsid Proteins
- Nucleoproteins
- Peptides
- Protein Binding
- RNA-Binding Proteins
- Spinal Diseases