Article
The design of a new mutation model for active genes: expression of the Escherichia coli lac operon in mammalian cells.
Mutation research - 1 Sept 1997
van Sloun P P, Lohman P H, Vrieling H
Abstract excerpt
The design of a novel transgenic mouse model is described that should allow analysis of mutations at a single cell level in all tissues of a model animal. The model is based on the correct regulation of the Escherichia coli lac operon in mammalian cells. Induction of a mutation in the lacI gene will result in the loss of transcriptional repression of the lacZ gene in mutated cells. Expression of...
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