Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[A novel bifunctional in vivo mutation detection system].

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica - 1 Mar 2002

Yao Zhen-Zhen, Li Huai-Xing, Che Wen-Liang, He Yan, Fu Ji-Lang

Abstract excerpt

A shuttle plasmid pMCLacI/neo with two copies of LacI was integrated into mouse genome and a novel system which could detect in vivo mutation of both expression and silence genes was constructed, enabling the comparative analysis of their mutation spectra and mutant frequencies. 486 fertilized eggs from C57BL/6 mice with microinjected pMCLacI/neo plasmid were transferred into oviducts of 18 pseudo-pregnant mice,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Southern
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Genome

Share to Lac Repressors

Share to Mice, Inbred BALB C

Share to Plasmids

Share to Repressor Proteins

Source

Identifiers

PMID: 12006996

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[A novel bifunctional in vivo mutation detection system].PMID 12006996Read ↗

[Development of a mouse cell line containing stably integrated copies of pMCLacI/Neo plasmid: a model for studying mutations in vitro].Semantic proximity Read ↗

[Experimental study of use of shuttle vector to develop a system of detecting mutagenesis in mammalian cells].Semantic proximity Read ↗

[A new strategy for detecting Lac I mutants based on pMCLac I/neo transgenic mice].Semantic proximity Read ↗

[Development of mammalian somatic cell genetics].Semantic proximity Read ↗

ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes.Semantic proximity Read ↗

A model system for analyzing somatic mutations in Drosophila melanogaster.Semantic proximity Read ↗

Detection and analysis of somatic mutations at a lacZ reporter locus in higher organisms: application to Mus musculus and Drosophila melanogaster.Semantic proximity Read ↗

Necessity of integrated genomic analysis to establish a designed knock-in mouse from CRISPR-Cas9-induced mutants.Semantic proximity Read ↗

A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice.Semantic proximity Read ↗

Plasmid-based transgenic mouse model for studying in vivo mutations.Semantic proximity Read ↗

[Progresses in mouse chromosome engineering].Semantic proximity Read ↗

Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.