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Article

Reactivation of heritably silenced gene expression in mice.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2000

Sutherland H G, Kearns M, Morgan H D, Headley A P, Morris C, Martin D I, Whitelaw E

Abstract excerpt

Epigenetic modifications that suppress gene activity in mammals are generally considered to be cleared in the germline, restoring totipotency of the genome. Here we report the germline inheritance of transcriptional silencing in mice, and reversion to activity after as many as three generations in the silent state. In a series of lines made with a LacZ transgene, one line exhibits variable expressivity:...

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Identifiers

PMID: 10790532
DOI: 10.1007/s003350010066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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