Article
Effects of O (6)-alkylguanine-DNA alkyltransferase deficiency in Escherichia coli as the host for the detection of mutations in lacI transgenic mice.
Environmental and molecular mutagenesis - 1 Jan 1999
Sui H, Suzuki M, Yamada M, Hara T, Kawakami K, Shibuya T, Nohmi T, Sofuni T
Abstract excerpt
Transgenic mice are widely used to detect gene mutations in vivo induced by a variety of chemicals. It is known, however, that no mutagenicity of methyl methanesulfonate (MMS) is detected in epididymal sperm in various transgenic mice assays, although MMS induces the dominant lethal and specific locus mutations in male mice. To investigate the issue of whether unrepaired lesions in DNA of mature sperm can be...
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