Article
An in situ protocol for measuring the expression of chemically-induced mutations in mammalian cells.
Mutation research - 1 Apr 1994
Spencer D L, Hines K C, Caspary W J
Abstract excerpt
The generation of expression curves and the evaluation of mutagenic responses of mammalian cells using standard mutagenesis assays can be inaccurate because mutant and wild-type cells are usually mixed during the expression phase. If some mutant progenitors or mutants grow more slowly than the wi...
Topics
- Animals
- Azacitidine
- Cell Division
- Cell Separation
- Cytarabine
- Dose-Response Relationship, Drug
- Drug Resistance
- Leukemia L5178
- Mice
- Mutagenesis, Site-Directed
- Mutagenicity Tests
- Mutagens
- Phenotype
- Reproducibility of Results
- Thymidine Kinase
- Trifluridine
- Tumor Cells, Cultured