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Article

K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.

Journal of surgical oncology - 1 Oct 1997

Yamanaka S, Tomioka T, Tajima Y, Okada K, Shiku H, Kanematsu T

Abstract excerpt

BACKGROUND AND OBJECTIVES: In our laboratory, we have developed a new model of carcinoma of the bile duct in Syrian golden hamsters, using N-nitrosobis(2-oxopropyl)amine (BOP). Morphologic and biologic characteristics of the carcinoma induced in this model are similar to those seen in humans. In order to examine the gene-related carcinogenesis of intrahepatic bile duct carcinoma, we investigated mutations in the...

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Identifiers

PMID: 9354164
DOI: 10.1002/(sici)1096-9098(199710)66:2<97::aid-jso5>3.0.co;2-g

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K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.PMID 9354164Read ↗

K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.Semantic proximity Read ↗

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Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12.Semantic proximity Read ↗

The Role of K-Ras and P53 in Biliary Tract Carcinoma.Semantic proximity Read ↗

Alterations in the Fhit gene in pancreatic duct adenocarcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters.Semantic proximity Read ↗

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Mutations of KRAS and TP53 in a minor proportion of Opisthorchis viverrini-associated cholangiocarcinomas in a hamster model.Semantic proximity Read ↗

Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas.Semantic proximity Read ↗

Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors.Semantic proximity Read ↗

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Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

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