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Article

K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.

Journal of surgical oncology - 1 Oct 1997

Yamanaka S, Tomioka T, Tajima Y, Okada K, Shiku H, Kanematsu T

Abstract excerpt

BACKGROUND AND OBJECTIVES: In our laboratory, we have developed a new model of carcinoma of the bile duct in Syrian golden hamsters, using N-nitrosobis(2-oxopropyl)amine (BOP). Morphologic and biologic characteristics of the carcinoma induced in this model are similar to those seen in humans. In...

Topics

Adenocarcinoma
Adenocarcinoma, Papillary
Animals
Bile Duct Neoplasms
Bile Ducts, Intrahepatic
Carcinogens
Cricetinae
Female
Genes, ras
Mesocricetus
Mutation
Nitrosamines

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Identifiers

PMID: 9354164
DOI: 10.1002/(sici)1096-9098(199710)66:2<97::aid-jso5>3.0.co;2-g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9354164-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.PMID 9354164Read ↗

K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.Semantic proximity Read ↗

High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.Semantic proximity Read ↗

K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters.Semantic proximity Read ↗

Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12.Semantic proximity Read ↗

The Role of K-Ras and P53 in Biliary Tract Carcinoma.Semantic proximity Read ↗

Alterations in the Fhit gene in pancreatic duct adenocarcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters.Semantic proximity Read ↗

KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas.Semantic proximity Read ↗

Mutations of KRAS and TP53 in a minor proportion of Opisthorchis viverrini-associated cholangiocarcinomas in a hamster model.Semantic proximity Read ↗

Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas.Semantic proximity Read ↗

Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors.Semantic proximity Read ↗

Mechanistic analysis of pancreatic ductal carcinogenesis in hamsters.Semantic proximity Read ↗

Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

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