High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.

Abstract excerpt

Ductal adenocarcinoma, the most common form of pancreatic cancer in humans, is associated with activation of the K-ras oncogene in approximately 90% of cases. In contrast, K-ras mutations are found in < 50% of the relatively rare intraductal papillary mucinous tumor (IPMT), which arises in the ma...

Topics

• Adenocarcinoma, Mucinous
• Animals
• Base Sequence
• Carcinoma, Ductal, Breast
• Cricetinae
• Female
• Genes, ras
• Liver Neoplasms, Experimental
• Mesocricetus
• Molecular Sequence Data
• Mutation
• Pancreatic Neoplasms
• Polymorphism, Restriction Fragment Length