Article
K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters.
Japanese journal of cancer research : Gann - 1 Nov 1993
Tsutsumi M, Kondoh S, Noguchi O, Horiguchi K, Kobayashi E, Okita S, Ohashi K, Honoki K, Tsujiuchi T, Konishi Y
Abstract excerpt
The presence of K-ras gene mutation was examined in experimentally induced preneoplastic pancreatic ductal lesions. Syrian hamsters received 70 mg/kg of N-nitrosobis(2-oxopropyl)amine (BOP) followed by repeated exposure to an augmentation pressure regimen consisting of choline-deficient diet comb...
Topics
- Animals
- Base Sequence
- Carcinoma
- Codon
- Cricetinae
- DNA Primers
- Female
- Genes, ras
- Hyperplasia
- Mesocricetus
- Molecular Sequence Data
- Mutagens
- Mutation
- Nitrosamines
- Pancreatic Ducts
- Pancreatic Neoplasms