Article
KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas.
Cancer - 1 May 2013
Hsu Maylee, Sasaki Motoko, Igarashi Saya, Sato Yasunori, Nakanuma Yasuni
Abstract excerpt
BACKGROUND: Similar to the pancreatic intraepithelial neoplasia (PanIN)-pancreatic carcinoma sequence model, intrahepatic cholangiocarcinoma (ICC) also reportedly follows a stepwise carcinogenesis process through the a precursor lesion: biliary intraepithelial neoplasia (BilIN). For this study, the authors investigated the status of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and GNAS complex...
Topics
- Base Sequence
- Bile Duct Neoplasms
- Bile Ducts, Intrahepatic
- Biliary Tract Neoplasms
- Cholangiocarcinoma
- Chromogranins
- DNA Primers
- GTP-Binding Protein alpha Subunits, Gs
- Genes, p53
- Genes, ras
- Humans