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Article

Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors.

Carcinogenesis - 1 Feb 2004

Li Junan, Weghorst Christopher M, Tsutsumi Masahiro, Poi Ming J, Knobloch Thomas J, Casto Bruce C, Melvin W Scott, Tsai Ming-Daw, Muscarella Peter

Abstract excerpt

The p16INK4A/CDKN2A (p16) tumor suppressor gene is known to be inactivated in up to 98% of human pancreatic cancer specimens. Chemically induced pancreatic tumors in Syrian golden hamsters have been demonstrated to share many morphological and biological similarities with human pancreatic tumors and represent a potentially suitable model for the evaluation of therapies targeting p16. The purpose of this study was...

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PMID: 14604895
DOI: 10.1093/carcin/bgh007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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