Article
Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12.
Molecular carcinogenesis - 1 Jan 1990
Fujii H, Egami H, Chaney W, Pour P, Pelling J
Abstract excerpt
We have used the polymerase chain reaction and dideoxynucleotide sequencing to amplify and sequence exons 1 and 2 of the c-Ki-ras proto-oncogene from the normal Syrian golden hamster. Similar methods were employed to screen for the presence of point mutations in the c-Ki-ras oncogene in primary h...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Carcinoma, Intraductal, Noninfiltrating
- Cricetinae
- Exons
- Mesocricetus
- Molecular Sequence Data
- Mutation
- Nitrosamines
- Oncogenes
- Pancreatic Neoplasms
- Polymerase Chain Reaction
- Proto-Oncogene Mas
- Proto-Oncogene Proteins p21(ras)