Article
Mutations of KRAS and TP53 in a minor proportion of Opisthorchis viverrini-associated cholangiocarcinomas in a hamster model.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2000
Tangkawattana Sirikachorn, Kaewkes Sasithorn, Pairojkul Chawalit, Tangkawattana Prasarn, Sripa Banchob
Abstract excerpt
BACKGROUND/AIMS: KRAS oncogene and TP53 tumor suppressor gene have been known as common genes involving in many cancers including cholangiocarcinoma (CCC). Activation of these genes could lead to uncontrolled proliferation and cancer ultimately. The aim of this study was to investigate mutation of KRAS exon 1 and TP53 exon 5-8 in Opisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) in a hamster model....
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