Article
Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas.
Cell reports - 23 Feb 2021
Tomita Hiroyuki, Tanaka Kaori, Hirata Akihiro, Okada Hideshi, Imai Hisashi, Shirakami Yohei, Ohnishi Kotaro, Sugie Shigeyuki, Aoki Hitomi, Hatano Yuichiro, Noguchi Kei, Kanayama Tomohiro, Niwa Ayumi, Suzui Natsuko, Miyazaki Tatsuhiko, Tanaka Takuji, Akiyama Haruhiko, Shimizu Masahito, Yoshida Kazuhiro, Hara Akira
Abstract excerpt
Evidence regarding intraductal papillary neoplasm of the bile duct (IPNB) as a type of precancerous lesion of cholangiocarcinoma is limited. Moreover, a reproducible in vivo model is lacking, and IPNB pathogenesis remains unclear. Here, we use a doxycycline-inducible tetracycline (Tet)-on mice model to control fibroblast growth factor 10 (FGF10) expression, which regulates branching and tubule formation....
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