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Article

K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.

Cancer research - 15 Aug 1992

Cerny W L, Mangold K A, Scarpelli D G

Abstract excerpt

K-ras oncogene mutation has been shown to be a frequent event in pancreatic ductal adenocarcinomas induced by the carcinogen N-nitroso-bis(2-oxopropyl)amine in the hamster. The present study examines the mutational status of the K-ras oncogene in lesions that precede the appearance of invasive ductal adenocarcinomas. Syrian golden hamsters (80-100 g) received 12 weekly doses of 15 mg/kg...

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Source

Identifiers

PMID: 1643642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.PMID 1643642Read ↗

K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters.Semantic proximity Read ↗

High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.Semantic proximity Read ↗

Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12.Semantic proximity Read ↗

Activation of c-K-ras is frequent in pancreatic carcinomas of Syrian hamsters, but is absent in pancreatic tumors of rats.Semantic proximity Read ↗

K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.Semantic proximity Read ↗

Detection of codon 12 mutation in the K-ras oncogene in pancreatic tumors.Semantic proximity Read ↗

Multiple genetic alterations in hamster pancreatic ductal adenocarcinomas.Semantic proximity Read ↗

Only wild-type c-Ki-ras codons 12, 13, and 61 in human pancreatic acinar cell carcinomas.Semantic proximity Read ↗

Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia.Semantic proximity Read ↗

Alterations in the Fhit gene in pancreatic duct adenocarcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters.Semantic proximity Read ↗

Mutational activation of K-ras in nonneoplastic exocrine pancreatic lesions in relation to cigarette smoking statusSemantic proximity Read ↗

K‐ <i>ras</i> oncogene activation in lung adenocarcinomas from former smokers evidence that K‐ <i>ras</i> mutations are an early and irreversible event in the development of adenocarcinoma of the lungSemantic proximity Read ↗

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