Article
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
Cancer research - 15 Aug 1992
Cerny W L, Mangold K A, Scarpelli D G
Abstract excerpt
K-ras oncogene mutation has been shown to be a frequent event in pancreatic ductal adenocarcinomas induced by the carcinogen N-nitroso-bis(2-oxopropyl)amine in the hamster. The present study examines the mutational status of the K-ras oncogene in lesions that precede the appearance of invasive du...
Topics
- Adenocarcinoma
- Animals
- Carcinogens
- Cricetinae
- DNA Mutational Analysis
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Hyperplasia
- Mesocricetus
- Mutation
- Nitrosamines
- Pancreatic Ducts
- Pancreatic Neoplasms
- Polymerase Chain Reaction
- Precancerous Conditions