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Article

In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia.

Gastroenterology - 1 Nov 1997

Licato L L, Keku T O, Wurzelmann J I, Murray S C, Woosley J T, Sandler R S, Brenner D A

Abstract excerpt

BACKGROUND & AIMS: To investigate whether mitogen-activated protein kinase (MAPK) cascades might play a role in the progression of colon cancer, c-Jun N-terminal kinase (JNK) and extracellular signal regulating kinase (ERK) activity during colonic tumorigenesis were examined. METHODS: The 1,2-dimethylhydrazine (DMH)-induced colon carcinoma model was used to study the activation of these kinases during intestinal...

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Identifiers

PMID: 9352861
DOI: 10.1053/gast.1997.v113.pm9352861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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