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Article

Differences in carcinogenesis by the length of carcinogen exposure period in rat colon.

Digestive diseases and sciences - 1 Jan 2001

Endo T, Ookawa K, Tanaka M, Nakaji S, Tsuchida S, Sugawara K

Abstract excerpt

To clarify the carcinogenic factors--whether it is the kind of carcinogen or their length of exposure--that determine whether colorectal cancer develops from an adenoma or develops de novo in the absence of an adenoma, we histopathologically analyzed a total of 229 rat colon tumors induced by administration of 1,2-dimethyl-hydrazine (DMH) or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for three or 15 weeks. In...

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PMID: 11270774
DOI: 10.1023/a:1005613926089

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