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Article

p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor.

The Journal of biological chemistry - 21 May 2004

Qi Xiaomei, Tang Jun, Pramanik Rocky, Schultz Richard M, Shirasawa Senji, Sasazuki Takehiko, Han Jiahuai, Chen Guan

Abstract excerpt

Ras is the most characterized oncogene in human cancer, and yet there are no effective therapeutics to selectively target this oncogene. Our previous work demonstrated the inhibitory activity of the p38 pathway in Ras proliferative signaling in experimental NIH 3T3 cells (Chen, G., Hitomi, M., Han, J., and Stacey, D. W. (2000) J. Biol. Chem. 275, 38973-38980). Here we explore the therapeutic potential of p38...

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PMID: 15037631
DOI: 10.1074/jbc.M313964200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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