Article
Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma.
Hepatology (Baltimore, Md.) - 1 Dec 1997
McKillop I H, Schmidt C M, Cahill P A, Sitzmann J V
Abstract excerpt
The mitogen-activated protein kinase (MAPK) cascade acts as a focal point for signal transduction following activation of both G-protein-linked and tyrosine kinase growth factor receptors. A common intermediate between both of these diverse receptor subtypes includes the small guanosine triphosphate (GTP)-binding protein, p21ras. Point mutations of p21ras have been identified in various tumor types and lead to...
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