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Article

Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors.

Oncotarget - 20 Apr 2015

Gupta Jalaj, Igea Ana, Papaioannou Marilena, Lopez-Casas Pedro Pablo, Llonch Elisabet, Hidalgo Manuel, Gorgoulis Vassilis G, Nebreda Angel R

Abstract excerpt

Colorectal cancer is a major health problem and the second cause of cancer related death in western countries. Signaling pathways that control tissue homeostasis are often deregulated during tumorigenesis and contribute to tumor development. Studies in mouse models have shown that the p38 MAPK pathway regulates homeostasis in colon epithelial cells but also plays an important role in colon tumor maintenance. In...

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Source

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Identifiers

PMID: 25890501
DOI: 10.18632/oncotarget.3816
PMCID: PMC4496165

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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