Article
No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies.
Neuroreport - 10 Nov 1997
Singleton A B, Lamb H, Leake A, McKeith I G, Ince P G, Perry R H, Morris C M
Abstract excerpt
The discovery of mis-sense mutations linking the presenilin-1 (PS-1) gene on chromosome 14 to Alzheimer's disease (AD) has lead to a thorough investigation of this locus. The PS-1 gene contains a polymorphism creating two alleles. The most common allele, allele 1, has been linked with late-onset...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Chromosome Mapping
- Chromosomes, Human, Pair 14
- Dementia
- Genotype
- Humans
- Lewy Bodies
- Membrane Proteins
- Parkinson Disease
- Polymorphism, Genetic
- Presenilin-1