Article
No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies.
Neuroreport - 10 Nov 1997
Singleton A B, Lamb H, Leake A, McKeith I G, Ince P G, Perry R H, Morris C M
Abstract excerpt
The discovery of mis-sense mutations linking the presenilin-1 (PS-1) gene on chromosome 14 to Alzheimer's disease (AD) has lead to a thorough investigation of this locus. The PS-1 gene contains a polymorphism creating two alleles. The most common allele, allele 1, has been linked with late-onset AD. Given the clinical and pathological overlaps between AD and dementia with Lewy bodies we genotyped 46...
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