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Article

Association between a PS-1 intronic polymorphism and late onset Alzheimer's disease.

Neuroreport - 2 Sept 1996

Kehoe P, Williams J, Holmans P, Liddell M, Lovestone S, Holmes C, Powell J, Neal J, Wilcock G, Owen M J

Abstract excerpt

Previous work suggests an association between allele 1 and the 1-1 genotype of an intronic polymorphism in the presenilin-1 (PS-1) gene and late onset Alzheimer's disease. We found an excess of the 1-1 genotype in our late onset clinical sample (p = 0.006, one-tailed) but not in our postmortem co...

Topics

Age of Onset
Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Family
Female
Genotype
Humans
Introns
Linkage Disequilibrium
Male
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Presenilin-1

Regression Analysis

Risk Factors

Source

Identifiers

PMID: 8930979
DOI: 10.1097/00001756-199609020-00019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8930979-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Association between a PS-1 intronic polymorphism and late onset Alzheimer's disease.PMID 8930979Read ↗

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A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset.Semantic proximity Read ↗

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