Article
Presenilin-1 gene intronic polymorphism in sporadic and familial Alzheimer's disease.
Neuroscience letters - 31 Jan 1997
Sorbi S, Nacmias B, Tedde A, Forleo P, Piacentini S, Latorraca S, Amaducci L
Abstract excerpt
A recent observation has shown a genetic association between an intronic polymorphism in the Presenilin-1 (PS-1) gene and late onset Alzheimer's disease (AD). The homozygosity of the 1 allele in the PS-1 gene was associated with a doubling of the risk for late onset AD. However, contrasting resul...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Family Health
- Gene Frequency
- Genotype
- Humans
- Introns
- Membrane Proteins
- Middle Aged
- Mutation