Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA).

doi:10.1006/taap.1997.8159

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Article

Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA).

Toxicology and applied pharmacology - 1 Jun 1997

Stauber A J, Bull R J

Abstract excerpt

Dichloroacetate (DCA) and trichloroacetate (TCA) are two hepatocarcinogenic by-products of water chlorination. To compare the effects of DCA and TCA on cell replication in the nodules and tumors they induce, male B6C3F1 mice were administered 2.0 g/L DCA or TCA in their drinking water for 38 or 5...

Topics

Administration, Oral
Animals
Cell Count
Cell Division
Dichloroacetic Acid
Drinking
Immunohistochemistry
Liver
Liver Neoplasms
Male
Mice
Phenotype
Precancerous Conditions
Trichloroacetic Acid

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