Article
Druckery slope controlled by mitotic rate of enzymatically-altered foci.
Journal of theoretical biology - 21 Mar 1991
Travis C C, Birkner P D
Abstract excerpt
Data on hepatocellular foci and tumors for four hepatocarcinogens are analyzed within the framework of a two-mutation model of oncogenesis to determine the biological factor(s) that control the values of N in Druckery's formula DTN = K, where T is the time to 50% tumor incidence at a daily dose D...
Topics
- Animals
- Carcinogens
- Incidence
- Liver Neoplasms, Experimental
- Mitosis
- Models, Biological
- Mutation
- Rats
- Time Factors