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Article

Druckery slope controlled by mitotic rate of enzymatically-altered foci.

Journal of theoretical biology - 21 Mar 1991

Travis C C, Birkner P D

Abstract excerpt

Data on hepatocellular foci and tumors for four hepatocarcinogens are analyzed within the framework of a two-mutation model of oncogenesis to determine the biological factor(s) that control the values of N in Druckery's formula DTN = K, where T is the time to 50% tumor incidence at a daily dose D. The two-mutation oncogenic model was found to adequately reproduce the empirical data for all four hepatocarcinogens....

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PMID: 2062093
DOI: 10.1016/s0022-5193(05)80278-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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