Article
The influence of MT-2 tropism on the prognostic implications of the delta32 deletion in the CCR-5 gene.
AIDS (London, England) - 1 Oct 1997
Bratt G, Sandström E, Albert J, Samson M, Wahren B
Abstract excerpt
BACKGROUND: Long-term non-progression in HIV-1-infected patients has been reported to be associated with a 32 base-pair deletion (delta32) in one CCR-5 allele. The normal gene product acts as a coreceptor for HIV cell entry and is essential for infection of cells by non-syncytium-inducing and MT-2-negative HIV-1 strains. METHODS: Forty individuals were studied, all of whom had been HIV-1-seropositive for a mean...
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