Article
Association between a defective CCR-5 gene and progression to disease in HIV infection.
AIDS research and human retroviruses - 20 Sept 1998
Balfe P, Churcher Y, Penny M, Easterbrook P J, Goodall R L, Galpin S, Gotch F, Daniels R S, McKeating J A
Abstract excerpt
We measured the effect(s) of CCR-5 genotype on disease progression by studying the frequency of a defective CCR-5 delta32 allele within a cohort of long-term infected individuals. An elevated frequency of CCR-5 delta32 heterozygotes within the cohort compared with a control population of blood do...
Topics
- Alleles
- Amino Acid Sequence
- Chemokines
- Cohort Studies
- Consensus Sequence
- Disease Progression
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Envelope Protein gp160
- HIV Infections
- HIV Long-Term Survivors
- HIV-1
- Heterozygote
- Humans
- Molecular Sequence Data
- Peptide Fragments
- Receptors, CCR5
- Time Factors