Article
Increased frequency of CCR-5 delta 32 heterozygotes among long-term non-progressors with HIV-1 infection. The Australian Long-Term Non-Progressor Study Group.
AIDS (London, England) - 1 Dec 1997
Stewart G J, Ashton L J, Biti R A, Ffrench R A, Bennetts B H, Newcombe N R, Benson E M, Carr A, Cooper D A, Kaldor J M
Abstract excerpt
BACKGROUND: The beta-chemokine receptor CCR-5 is used as a coreceptor by macrophage-tropic strains of HIV-1 to gain entry into CD4+ cells. OBJECTIVE: To determine the effect of a common 32 base-pair deletion mutation in the CCR-5 gene (CCR-5 delta 32) on progression of HIV infection to AIDS, and...
Topics
- Disease Progression
- Gene Frequency
- Genotype
- HIV Infections
- Heterozygote
- Humans
- Receptors, CCR5
- Survivors
- Time Factors