Article
Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2000
Romiti M L, Colognesi C, Cancrini C, Mas A, Berrino M, Salvatori F, Orlandi P, Jansson M, Palomba E, Plebani A, Bertran J M, Hernandez M, de Martino M, Amoroso A, Tovo P A, Rossi P, Espanol T, Scarlatti G
Abstract excerpt
BACKGROUND: A deletion of 32 base pairs in the CCR5 gene (delta32 CCR5) has been linked to resistance to HIV-1 infection in exposed adults and to the delay of disease progression in infected adults. MATERIALS AND METHODS: To determine the role of delta32 CCR5 in disease progression of HIV-1 infected children born to seropositive mothers, we studied a polymerase chain reaction in 301 HIV-1 infected, 262 HIV-1...
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