Article
Association between CCR5 genotype and the clinical course of HIV-1 infection.
Annals of internal medicine - 15 Nov 1997
de Roda Husman A M, Koot M, Cornelissen M, Keet I P, Brouwer M, Broersen S M, Bakker M, Roos M T, Prins M, de Wolf F, Coutinho R A, Miedema F, Goudsmit J, Schuitemaker H
Abstract excerpt
BACKGROUND: Heterozygosity for a 32-nucleotide deletion in the C-C chemokine receptor 5 gene (CCR5 delta 32) is associated with delayed disease progression in persons infected with HIV-1. OBJECTIVE: To compare the predictive value of CCR5 genotype with that of established markers in the clinical...
Topics
- Acquired Immunodeficiency Syndrome
- Biomarkers
- CD4 Lymphocyte Count
- Case-Control Studies
- Disease Progression
- Genotype
- HIV Antibodies
- HIV Infections
- HIV-1
- Heterozygote
- Humans
- Life Tables
- Longitudinal Studies
- Male