Article
Association between CCR5 genotype and the clinical course of HIV-1 infection.
Annals of internal medicine - 15 Nov 1997
de Roda Husman A M, Koot M, Cornelissen M, Keet I P, Brouwer M, Broersen S M, Bakker M, Roos M T, Prins M, de Wolf F, Coutinho R A, Miedema F, Goudsmit J, Schuitemaker H
Abstract excerpt
BACKGROUND: Heterozygosity for a 32-nucleotide deletion in the C-C chemokine receptor 5 gene (CCR5 delta 32) is associated with delayed disease progression in persons infected with HIV-1. OBJECTIVE: To compare the predictive value of CCR5 genotype with that of established markers in the clinical course of HIV-1 infection. DESIGN: Retrospective longitudinal study and nested case-control study. The latter included...
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