Chemokine receptor allelic polymorphisms: relationships to HIV resistance and disease progression.

doi:10.1006/smim.1998.0132

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Article

Chemokine receptor allelic polymorphisms: relationships to HIV resistance and disease progression.

Seminars in immunology - 1 Jun 1998

Paxton W A, Kang S

Abstract excerpt

It is now well established that an array of CC and CXC chemokine receptors, in association with the CD4 molecule, can interact with the HIV-1 gp120 protein to facilitate viral fusion. A 32bp deletion in the CC chemokine receptor CCR5, the major M-tropic viral co-receptor, provides considerable pr...

Topics

Alleles
Genetic Predisposition to Disease
HIV Infections
HIV-1
Humans
Polymorphism, Genetic
Receptors, Chemokine

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