Article
MT-2 tropism and CCR-5 genotype strongly influence disease progression in HIV-1-infected individuals.
AIDS (London, England) - 7 May 1998
Bratt G, Leandersson A C, Albert J, Sandström E, Wahren B
Abstract excerpt
BACKGROUND: The beta-chemokine receptor CCR-5 is the coreceptor for cellular entry by non-syncytium-inducing (NSI) HIV-1 strains that dominate early in infection. A 32 base-pair deletion (delta32) in the CCR-5 gene renders this coreceptor non-functional. Heterozygosity for this deletion [delta32/...
Topics
- AIDS Vaccines
- Adult
- Aged
- CD4 Lymphocyte Count
- Cell Line, Transformed
- Cohort Studies
- Cross-Sectional Studies
- Disease Progression
- Follow-Up Studies
- Genotype
- HIV Envelope Protein gp160
- HIV Infections