Article
Regulation of cytoskeleton by myelin components: studies on shiverer oligodendrocytes carrying an Mbp transgene.
Developmental neuroscience - 1 Jan 1997
Dyer C A, Phillbotte T, Wolf M K, Billings-Gagliardi S
Abstract excerpt
Oligodendrocytes from the shiverer mutant mouse are missing most of the myelin basic protein (Mbp) gene. In axon-free cultures, they produce membrane sheets with abnormally assembled microtubule and actin-based structures. This suggests that an Mbp gene product may have an important role in regul...
Topics
- 2',3'-Cyclic-Nucleotide Phosphodiesterases
- Actins
- Animals
- Cell Division
- Cell Nucleus
- Cytoskeleton
- Female
- Galactosylceramidase
- Isomerism
- Male
- Mice
- Mice, Neurologic Mutants
- Mice, Transgenic
- Microtubules
- Mutation
- Myelin Basic Protein
- Oligodendroglia
- Protein Structure, Tertiary