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Article

Integrin Signaling in Oligodendrocytes and Its Importance in CNS Myelination

20 Dec 2010

Abstract excerpt

Multiple sclerosis is characterized by repeated demyelinating attacks of the central nervous system (CNS) white matter tracts. To tailor novel therapeutics to halt or reverse disease process, we require a better understanding of oligodendrocyte biology and of the molecular mechanisms that initiate myelination. Cell extrinsic mechanisms regulate CNS myelination through the interaction of extracellular matrix...

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PMID: 21637375
DOI: 10.1155/2011/354091

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