Evidence for central nervous system glial cell plasticity in phenylketonuria.

doi:10.1097/00005072-199607000-00005

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Article

Evidence for central nervous system glial cell plasticity in phenylketonuria.

Journal of neuropathology and experimental neurology - 1 Jul 1996

Dyer C A, Kendler A, Philibotte T, Gardiner P, Cruz J, Levy H L

Abstract excerpt

Phenylketonuria (PKU) is caused by mutation(s) in the phenylalanine hydroxylase (PAH) gene which lead to deficient PAH activity and an accumulation of phenylalanine in the blood. The primary pathologic finding is hypomyelination and gliosis of central nervous system white matter. Similar white matter pathology is observed in the Pahenu2 mouse, a genetic model for PKU. We studied this mouse to examine the basis...

Topics

Adult
Animals
Biomarkers
Brain
Glial Fibrillary Acidic Protein
Gliosis
Humans
Mice
Mice, Mutant Strains
Mutation
Myelin Basic Protein
Myelin Sheath
Neuroglia
Neuronal Plasticity
Oligodendroglia
Phenylalanine
Phenylalanine Hydroxylase
Phenylketonurias

Source

Open in PubMed

Identifiers

PMID: 8965095
DOI: 10.1097/00005072-199607000-00005

Genes

GFAP
MBP
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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