Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system.

doi:10.1007/s004410050866

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Article

Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system.

Cell and tissue research - 1 Aug 1997

Stoffel W, Boison D, Büssow H

Abstract excerpt

Myelination is an important developmental process of the central (CNS) and peripheral nervous system (PNS). To unravel the functions of the two dominant myelin proteins in the CNS, proteolipid protein (PLP) and myelin basic protein (MBP), we generated and characterized the homozygous double mutant mouse line (plp-/-, mbp-/-), which is viable and fertile. Plasma membrane processes of oligodendrocytes deficient in...

Topics

Animals
Central Nervous System
Female
Galactosyltransferases
Ganglioside Galactosyltransferase
Genotype
Male
Mice
Mice, Knockout
Microscopy
Microscopy, Electron

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Myelin Basic Protein

Myelin Proteolipid Protein

Myelin Sheath

Myelin-Associated Glycoprotein

RNA

Source

Open in PubMed

Identifiers

PMID: 9211822
DOI: 10.1007/s004410050866

Genes

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