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Article

Generation of a LacZ reporter transgenic mouse line for the stereological analysis of oligodendrocyte loss in galactosylceramidase deficiency.

Journal of neuroscience research - 1 Dec 2016

Zhu Hongling, Ornaghi Francesca, Belin Sophie, Givogri Maria I, Wrabetz Lawrence, Bongarzone Ernesto R

Abstract excerpt

Krabbe's disease is a leukodystrophy resulting from deficiency of galactosylceramidase and the accumulation of galactosylsphingosine (psychosine) in the nervous system. Psychosine is believed to cause central demyelination by killing oligodendrocytes. Quantitative analysis of this process is lacking. To address this, we generated a new transgenic reporter twitcher line in which myelinating oligodendrocytes are...

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Identifiers

PMID: 27426866
DOI: 10.1002/jnr.23839
PMCID: PMC5069144

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MBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Generation of a LacZ reporter transgenic mouse line for the stereological analysis of oligodendrocyte loss in galactosylceramidase deficiency.PMID 27426866Read ↗

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