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Article

Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Oct 1997

Zhang F, Eckman C, Younkin S, Hsiao K K, Iadecola C

Abstract excerpt

We studied the role of the amyloid precursor protein (APP) in ischemic brain damage using transgenic mice overexpressing APP. The middle cerebral artery (MCA) was occluded in FVB/N mice expressing APP695.SWE (Swedish mutation) and in nontransgenic littermates. Infarct volume (cubic millimeters) was assessed 24 hr later in thionin-stained brain sections. The infarct produced by MCA occlusion was enlarged in the...

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Source

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Identifiers

PMID: 9315887
PMCID: PMC6793926

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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