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Article

Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice.

Brain research - 19 Oct 2009

Kitaguchi Hiroshi, Tomimoto Hidekazu, Ihara Masafumi, Shibata Masunari, Uemura Kengo, Kalaria Rajesch N, Kihara Takeshi, Asada-Utsugi Megumi, Kinoshita Ayae, Takahashi Ryosuke

Abstract excerpt

Chronic cerebral ischemia may accelerate clinicopathological changes in Alzheimer's disease. We have examined whether chronic cerebral hypoperfusion accelerates amyloid beta deposition in amyloid protein precursor transgenic (APP-Tg) mouse. At 5, 8, and 11 months of age, C57Bl/6J male mice overex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19646974
DOI: 10.1016/j.brainres.2009.07.078

Genes

APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19646974-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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